(M)-AVI-4773 is an orally active, blood-brain barrier permeable coronaviruses M Pro inhibitor with an IC 50 of 2.5 nM aginst SARS-CoV-2 M Pro . (M)-AVI-4773 produces a rapid onset antiviral effect in mouse models of MERS-CoV and SARS-CoV-2 infection .
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