PROTAC NTRK1 degrader-1

Overview

PROTAC NTRK1 degrader-1 is a wild-type and mutant NTRK1 PROTAC degrader with IC 50 values of 4 nM (wild-type), 2 nM (G595R), 5 nM (G667C), and <0.5 nM (F598L). PROTAC NTRK1 degrader-1 catalyzes ubiquitination and subsequent proteasome-mediated degradation of wild-type and mutant (G595R, G667C, F598L) NTRK1 . PROTAC NTRK1 degrader-1 can be used for the research of solid tumors. (Pink: NTRK1 ligand ( HY-185545 ); Blue: Cereblon ligand ( HY-W1115186 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-181052
• CAS No.: 2922274-35-7
• Molecular Formula: C38H35FN10O6
• Molecular Weight: 746.75
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source