PDE3/4-IN-4

Overview

PDE3/4-IN-4 is an orally active PDE3A and PDE4B inhibitor with IC 50 values of 10 nM and 9.4 nM, respectively. PDE3/4-IN-4 shows selective activity relative to most other PDE family members. PDE3/4-IN-4 modulates the cAMP/PKA/CREB signaling pathway. PDE3/4-IN-4 inhibits pro-inflammatory factor IL-6 . PDE3/4-IN-4 reduces expression of inflammatory markers in liver tissue. PDE3/4-IN-4 attenuates liver fibrosis. PDE3/4-IN-4 limits liver damage in cholestatic and sepsis-induced liver disease mice models. PDE3/4-IN-4 can be used for the research of liver injury, cholestatic liver diseases, sepsis-induced liver injury.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Disease | Products > Disease Areas > Liver Injury | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-181088
• CAS No.: 3088024-27-2
• Molecular Formula: C30H27F2N5O4
• Molecular Weight: 559.56
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source