PROTAC HMGCR Degrader-2

Overview

PROTAC HMGCR Degrader-2 is a HMGCR PROTAC degrader with an IC 50 value of 0.25 μM. PROTAC degrades HMGCR-2 in Insig-silenced HepG2 cells with a DC 50 of 0.12 μM. PROTAC HMGCR Degrader-2 takes PROTAC HMGCR Degrader-1 ( HY-171823 ) as the oral prodrug. PROTAC HMGCR Degrader-2 degrades HMGCR by the VHL -dependent ubiquitin-proteasome system and reduces cellular cholesterol in HepG2 cells. PROTAC CDK2/4/6 Degrader-2 can be used for hyperlipidemia research. (Pink: HMG-CoA Reductase (HMGCR) ligand ( HY-122439 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-W014831 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-181134
• CAS No.: 2715104-46-2
• Molecular Formula: C53H79N5O10S
• Molecular Weight: 978.29
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source