Lb54

Overview

Lb54 is a caspase-3 and caspase-7 activator with an EC 50 of 660.9 nM for human procaspase-3 . Lb54 activates caspase-3/7, which cleaves Gasdermin D (GSDMD) at aspartic acid residue 87 to generate a p10 fragment, preventing formation of the pore-forming p30 fragment of GSDMD. Lb54 suppresses GSDMD-mediated pyroptosis through caspase-3/7 activation, thereby attenuating inflammatory responses and conferring protection against sepsis. Lb54 alleviates acute lung injury, and inhibited systemic inflammation by restraining the maturation of monocyte-derived dendritic cells. Lb54 can be used for the research of sepsis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Sepsis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Pyroptosis

Product Information

• Catalog No.: HY-181168
• CAS No.: 97816-62-1
• Molecular Formula: C27H22N2O10S2
• Molecular Weight: 598.60
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source