PXS 25

Overview

PXS 25 is a cation-independent mannose 6-phosphate receptor (CI-M6PR) inhibitor that inhibits CI-M6PR -mediated activation of latent TGF-β 1 . PXS 25 inhibits conversion of high glucose-induced latent TGF-β 1 to active TGF-β 1 in proximal tubule cells under normoxic conditions. PXS 25 suppresses high glucose-induced fibronectin , collagen IV production, and phosphorylated Smad 2 in proximal tubule cells under normoxic conditions. PXS 25 has antifibrotic properties in skin fibroblasts. PXS 25 can be used for the research of diabetic nephropathy.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Type 1 Diabetes | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > TGF-beta/Smad

Product Information

• Catalog No.: HY-181430
• CAS No.: 798546-78-8
• Molecular Formula: C15H23O8P
• Molecular Weight: 362.31
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source