PXS 64

Overview

PXS 64, a mannose-6-phosphate (M6P) analogue. a lipophilic prodrug of PXS 25 ( HY-181430 ). PXS 64 is an effective anti-fibrotic agent by inhibiting the activation of latent TGF-β1 . PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts. PXS 64 reduces TGFβ-mediated collagen IV, fibronectin, MCP-1, and phospho- smad2 expression in kidney cells. PXS 64 reduces collagen deposition in dermal scar fibroblasts. PXS 64 can be used for the research of chronic kidney disease, idiopathic pulmonary fibrosis, scarring.

Application

Products | Products > Disease Areas > Chronic Kidney Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Renal Disease | Products > Disease Areas > Lung Fibrosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > TGF-beta/Smad

Product Information

• Catalog No.: HY-181431
• CAS No.: 1253691-50-7
• Molecular Formula: C27H43O12P
• Molecular Weight: 590.60
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source