NLRP3-IN-87

Overview

NLRP3-IN-87 is a selective and orally active NLRP3 inhibitor with a K d of 0.23 μM. NLRP3-IN-87 binds directly to the NLRP3 NACHT domain, disrupts NLRP3-NEK7 and NLRP3-ASC interactions, inhibits ASC oligomerization, and blocks inflammasome assembly. NLRP3-IN-87 suppresses caspase-1 activation and IL-1β secretion. NLRP3-IN-87 exhibits anti-inflammatory and analgesic activity, reducing joint swelling, inflammation, and pain in an MSU ( HY-B2130A )-induced acute gout mouse model. NLRP3-IN-87 can be used for the research of gout.

Application

Products | Products > Disease Areas > Arthritis | Products > Disease Areas > Purine Metabolism | Products > Disease Areas > Gout | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-181488
• CAS No.: 3097745-69-9
• Molecular Formula: C21H21BrN2O4S
• Molecular Weight: 477.37
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source