RAFKBP12

Overview

RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination. (Pink: FKBP12 ligand ( HY-114434 ); Blue: Proteasome ligand ( HY-181499 ); Black: linker).

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Others | Products > Signaling Pathways > Proteasome | Products > Signaling Pathways > Proteasome Cap Targeting Chimeras | Products > Signaling Pathways > FKBP

Product Information

• Catalog No.: HY-181498
• CAS No.: 2375455-59-5
• Molecular Formula: C79H93Cl4N5O17
• Molecular Weight: 1526.42
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source