Sim-9

Overview

Sim-9 is a covalent allosteric inhibitor of interferon regulatory factor 3 ( IRF3 ). Sim-9 binds covalently to the Cys222 residue of IRF3 , induces its conformational change, blocks its interactions with TRIF , MAVS and STING , and inhibits IRF3 homodimerization and type I interferon response. Sim-9 exhibits significant anti-inflammatory, organ-protective and survival benefits in mouse models of sepsis and acute pancreatitis. Sim-9 can be used for research related to inflammatory diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Pancreatitis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > STING

Product Information

• Catalog No.: HY-181526
• CAS No.: 3099101-40-0
• Molecular Formula: C31H28F3NO6
• Molecular Weight: 567.55
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source