ROCK2-IN-14

Overview

ROCK2-IN-14 is an orally active, selective ROCK2 inhibitor ( IC 50 =4.8 nM) with 212-fold selectivity over ROCK1 (IC 50 =1.01 μM). By inhibiting the ROCK2/S100A9 signaling pathway, ROCK2-IN-14 downregulates S100A9 expression, inhibits NM2 phosphorylation and restores cytoskeletal abnormalities. Furthermore, ROCK2-IN-14 reduces inflammatory cytokine levels, alleviates skin inflammation and exerts anti-inflammatory activity. ROCK2-IN-14 also significantly inhibits ear thickening in a mouse model of atopic dermatitis (AD), and decreases the levels of IgE , TNF-α, IL-6 and TSLP . ROCK2-IN-14 can be used for research on atopic dermatitis.

Application

Products | Products > Disease Areas > Atopic Dermatitis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Skin Inflammation | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > ROCK

Product Information

• Catalog No.: HY-181576
• CAS No.: 3115784-59-0
• Molecular Formula: C24H26N4O2S
• Molecular Weight: 434.55
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source