GPX4 degrader-1

Overview

GPX4 degrader-1 (Compound RS-1) is a hydrophobic tagging ( HyT )-mediated GPX4 degrader ( DC 50 : 8.9 nM in HT1080 cells) GPX4 degrader-1 induces GPX4 degradation. GPX4 degrader-1 induces Ferroptosis . GPX4 degrader-1 increases lipid ROS . GPX4 degrader-1 demonstrates potent antitumor efficacy in a murine mammary carcinoma model.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > HyT | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-181598
• CAS No.: 3057531-85-5
• Molecular Formula: C38H36ClN3O4
• Molecular Weight: 634.16
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source