MDH2-IN-2

Overview

MDH2-IN-2 is an orally active MDH2 inhibitor with an IC 50 of 5.9 μM. MDH2-IN-2 reduces the levels of senescence markers and senescence-associated secretory phenotype (SASP) factors in mammalian cell models. MDH2-IN-2 extends the lifespan and improves the healthspan of Caenorhabditis elegans. MDH2-IN-2 alleviates tissue senescence in aged mice, inhibits SASP factors, and restores liver and kidney functions. MDH2-IN-2 is applicable for senescence-related research.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Cellular Senescence | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Malate Dehydrogenase (MDH)

Product Information

• Catalog No.: HY-181604
• CAS No.: 3047410-41-0
• Molecular Formula: C31H40N2O4S
• Molecular Weight: 536.73
• Purity: 99.91%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (4.66 mM); Clear solution
• Availability: In-stock

Source

Original product source