LasB-IN-3

Overview

LasB-IN-3 is a protease elastase ( LasB ) inhibitor of Pseudomonas aeruginosa with an IC 50 value of 8.5 nM. LasB-IN-3 shows an IC 50 of 58.9 nM for the Met128Val mutant. LasB-IN-3 binds to active sites of wild-type and Met128Val mutant LasB, coordinates zinc ions, forms hydrogen bonds and CH-π interactions, and inhibits LasB proteolytic activity. LasB-IN-3 increases survival rate in LasB-induced acute lung injury mice models . LasB-IN-3 can be used for the research of Pseudomonas aeruginosa infection .

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Pseudomonas Aeruginosa Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Elastase

Product Information

• Catalog No.: HY-181647
• CAS No.: 2762675-42-1
• Molecular Formula: C18H21ClNO4P
• Molecular Weight: 381.79
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source