Snail IN-1

Overview

Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail - CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5 , CXCL10 , MMP2 , and MMP9 , and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Atherosclerosis and Inflammation | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Histone Acetyltransferase | Products > Signaling Pathways > MMP | Products > Signaling Pathways > CXCR | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-181654
• CAS No.: 3083216-69-4
• Molecular Formula: C21H23N5O2S
• Molecular Weight: 409.50
• Purity: 98.27%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution
• Availability: In-stock

Source

Original product source