dBET1

Overview

dBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC 50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 ( HY-13030 ) linked to NSC 527179 ( HY-14658 ) with a linker. (Pink: BRD4 ligand ( HY-78695 ); Blue: Cereblon ligand ( HY-103597 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-101838
• CAS No.: 1799711-21-9
• Molecular Formula: C38H37ClN8O7S
• Molecular Weight: 785.27
• Purity: 98.96%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 3 mg/mL (3.82 mM); Clear solution
• Availability: In-stock

Source

Original product source