HDAC3-IN-8

Overview

HDAC3-IN-8 is a selective inhibitor targeting HDAC1 , HDAC2 and HDAC3 , with IC 50 values of 3.52 nM for HDAC1 , 15.14 nM for HDAC2 and 0.38 nM for HDAC3 . HDAC3-IN-8 shows high selectivity for HDAC3 and exerts its effect by inhibiting histone deacetylase activity. HDAC3-IN-8 can be used to construct HDAC3-targeted PROTAC degrader ( HY-181767 ) and is suitable for the research of acute myeloid leukemia (AML).

Application

Products | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Lymphoblastic Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ligands for Target Protein for PROTAC | Products > Signaling Pathways > HDAC

Product Information

• Catalog No.: HY-181768
• CAS No.: 2763368-90-5
• Molecular Formula: C20H21N3O3
• Molecular Weight: 351.40
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source