Rolitetracycline

Overview

Rolitetracycline is a highly soluble, broad-spectrum antibiotic derived from tetracycline . Rolitetracycline binds to and stabilizes bovine serum albumin, and also inhibits HIV-1 integrase , blocks Aβ fibril formation and suppresses dengue virus proliferation. Rolitetracycline mediates the inhibition of Aβ fibrils via a specific three-dimensional pharmacophore conformation, and exerts bacteriostatic and bactericidal activities. Rolitetracycline acts synergistically with Penicillin G ( HY-N7139 ) or Cephalothin ( HY-B1275A ) to alter the effects on microbial growth. Rolitetracycline serves as an important tool compound for the study of bacterial infections (urinary tract infections, sepsis), HIV-1 and dengue virus infections, as well as Alzheimer's disease.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Genitourinary Inflammation | Products > Disease Areas > HIV Infection | Products > Disease Areas > Sexually Transmitted Disease | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Sepsis | Products > Disease Areas > Urinary Tract Infections | Products > Disease Areas > HIV-1 Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > Antibiotic | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Dengue Virus | Products > Signaling Pathways > Amyloid-β | Products > Signaling Pathways > HIV Integrase

Product Information

• Catalog No.: HY-18257
• CAS No.: 751-97-3
• Molecular Formula: C27H33N3O8
• Molecular Weight: 527.57
• Purity: 95.0%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source