YZ-836P

Overview

YZ-836P is a Protein arginine methyltransferase 5 ( PRMT5 ) targeting agent. YZ-836P promotes ubiquitination and proteasomal degradation of PRMT5 in a cereblon ( CRBN )-dependent manner, which in turn reduces levels of its downstream target KLF5 . YZ-836P induces G1 phase cell cycle arrest in triple-negative breast cancer cells. YZ-836P induces Apoptosis in triple-negative breast cancer cells. YZ-836P exerts cytotoxic effects on triple-negative breast cancer cells. YZ-836P inhibits the growth of triple-negative breast cancer patient-derived organoids. YZ-836P inhibits the growth of triple-negative breast cancer xenografts in nude mice. YZ-836P can be used for the research of triple-negative breast cancer . (Pink: PRMT5 ligand ( HY-173562 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker).

Application

Products | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Methyltransferase | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > KLF

Product Information

• Catalog No.: HY-182820
• CAS No.: 3086041-35-9
• Molecular Formula: C45H57N9O7
• Molecular Weight: 835.99
• Purity: 99.98%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source