HEP-50768

Overview

HEP-50768 is an orally active and selective MRGPRX4 ( hX4 ) antagonist. HEP-50768 suppresses basal and bile-acid-stimulated hX4 activity. HEP-50768 binds the receptor’s transmembrane pocket and induces extracellular loop rearrangements. HEP-50768 modulates GPCR microswitch motifs and reduces bile-acid-induced pruritic scratching behaviors. HEP-50768 can be used for the research of cholestatic pruritus.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Others | Products > Signaling Pathways > Mas-related G-protein-coupled Receptor (MRGPR)

Product Information

• Catalog No.: HY-183050
• CAS No.: 3036387-75-1
• Molecular Formula: C16H10F4N4O
• Molecular Weight: 350.27
• Purity: 99.17%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.14 mM); Clear solution
• Availability: In-stock

Source

Original product source