TRI-611

Overview

TRI-611 is a brain-penetrant, orally active molecular glue degrader targeting ALK . TRI-611 engages ALK via a distal degron, forms a ternary complex with CRBN, triggers ALK polyubiquitination and degradation, including TKI-resistant ALK fusion proteins. TRI-611 inhibits ALK downstream signaling pathways, induces anti-proliferative effects in ALK-positive cancer cells. TRI-611 induces regression of ALK-positive non-small cell lung cancer tumors in preclinical xenograft models . TRI-611 can be used for the research of ALK-positive non-small cell lung cancer , including TKI-refractory tumors and central nervous system metastases.

Application

Products | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > Anaplastic lymphoma kinase (ALK)

Product Information

• Catalog No.: HY-183116
• CAS No.: 3117940-39-0
• Molecular Formula: C21H16N4O5
• Molecular Weight: 404.38
• Purity: 99.07%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.18 mM); Suspended solution
• Availability: In-stock

Source

Original product source