LI-633

Overview

LI-633 is a selective and orally active GABAA receptor positive allosteric modulator (PAM) with a K i of 21 nM. LI-633 produces robust potentiation of GABA-induced inward current, with EC 50 values ranging from 8 nM (α5β2γ2) to 128 nM (α3β2γ2). LI-633 potentiates muscimol-induced GABAergic currents in rat dorsal root ganglion (DRG) neurons with an EC 50 of 70.4 nM. LI-633 can be used for the study of visceral pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > GABA Receptor

Product Information

• Catalog No.: HY-185007
• CAS No.: 1849624-82-3
• Molecular Formula: C18H11ClFN3O2
• Molecular Weight: 355.75
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source