GSK702

Overview

GSK702, a PROTAC , is a the less active cis-(S,S)-enantiomer of GSK983 (P300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) PROTAC ). GSK702 induces only a small decrease of PCAF protein levels. GSK702 binds to CRBN and causes a reduction of IL-1β in macrophages. GSK702 can be used for the study of inflammatory mediators. (Pink: GCN5/PCAF ligand ( HY-101027A ); Blue: Cereblon ligand ( HY-103596 ); Black: linker).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Histone Acetyltransferase | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-185009
• CAS No.: 2260944-69-0
• Molecular Formula: C45H51BrN8O7
• Molecular Weight: 895.84
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source