KT109

Overview

KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC 50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC 50 =1 µM). KT109 shows negligible activity against FAAH , MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol ( HY-W011051 ), Arachidonic acid ( HY-109590 ) and eicosanoids in mouse peritoneal macrophages.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MAGL | Products > Signaling Pathways > DAGL

Product Information

• Catalog No.: HY-18540
• CAS No.: 1402612-55-8
• Molecular Formula: C27H26N4O
• Molecular Weight: 422.52
• Purity: 99.86%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (5.92 mM); Clear solution; Need ultrasonic and warming and heat to 80°C
• Availability: In-stock

Source

Original product source