Azimilide dihydrochloride

Overview

Azimilide (NE-10064) dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of I Ks ( IC 50 = 2.6 μM (2mM [K⁺]ₑ)) and I Kr ( IC 50 = 1 μM (4 mM [K⁺])). Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC 50 s of 1.4 μM and 5.2 μM respectively. Azimilide dihydrochloride also inhibits L-type calcium current ( I Ca ) ( IC 50 = 17.8 μM) and sodium current ( I Na ) ( IC 50 = 19 μM). Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation.

Application

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Product Information

• Catalog No.: HY-18600A
• CAS No.: 149888-94-8
• Molecular Formula: C23H30Cl3N5O3
• Molecular Weight: 530.88
• Purity: 98.17%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source