Arg-PEG1-Dasa

Overview

Arg-PEG1-Dasa is a mini- PROTAC targeting BCR-ABL . Arg-PEG1-Dasa induces BCR-ABL degradation ( EC 50 = 0.85 nM) and shows antiproliferative activity in K562 cells ( IC 50 = 0.36 nM). Arg-PEG1-Dasa can be used for chronic myeloid leukemia research. (Pink: Bcr-Abl ligand ( HY-10181 ); Blue: Ligands for E3 Ligase ligand ( HY-N0455 ); Black: linker).

Application

Products | Products > Disease Areas > Chronic Myelogenous Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Bcr-Abl

Product Information

• Catalog No.: HY-186016
• CAS No.: 3037776-67-0
• Molecular Formula: C33H47ClN12O5S
• Molecular Weight: 759.32
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source