Diclofensine hydrochloride

Overview

Diclofensine (Ro 8-46500) hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC 50 values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine ( HY-W007606 )-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.

Application

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Product Information

• Catalog No.: HY-18610
• CAS No.: 34041-84-4
• Molecular Formula: C17H18Cl3NO
• Molecular Weight: 358.69
• Purity: 99.79%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 0.67 mg/mL (1.87 mM); Clear solution
• Availability: In-stock

Source

Original product source