TC-N 22A is a potent, selective, orally active and brain-permeable mGlu 4 PAM with an EC 50 of 9 nM in human mGlu 4 -expressing BHK cells. TC-N 22A is less active (EC 50 >10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo.
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