KAI-407

Overview

KAI-407 is an orally active inhibitor of Plasmodium PI4K kinase, which can broadly inhibit multiple stages of the parasite lifecycle. KAI-407 exhibits EC 50 s of for the blood stage of malignant Plasmodium of 81 nM; for the liver schizonts of P. yoelii of 88 nM; and IC 50 s for the liver schizonts and dormant bodies of P. cynomolgi of 0.64 μM and 0.69 μM respectively. KAI-407 can prevent Plasmodium berghei infection 100%. KAI-407 can be used for the study of vivax malaria.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Infection | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > PI4K

Product Information

• Catalog No.: HY-18746
• CAS No.: 1513879-18-9
• Molecular Formula: C22H14F3N5O
• Molecular Weight: 421.37
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source