Halofuginone

Overview

Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.

Application

Products > Drug Discovery > Impurities > Anti-Infectives > Halofuginone and Impurities | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B0084-071625
• CAS No.: 55837-20-2
• Molecular Formula: C16H17BrClN3O3
• Molecular Weight: 414.684
• Purity: > 95%
• Storage: -20°C

Source

Original product source