ME-3407 (EF-4040) is a H + -K + -ATPase redistribution disruptor and myosin light chain kinase ( MLCK ) and protein kinase A inhibitor. ME-3407 blocks gastric acid secretion and aminopyrine accumulation by inhibiting microsomal-to-apical membrane redistribution of H + -K + -ATPase and suppressing MLCK-mediated myosin light chain phosphorylation. ME-3407 is promising for research of peptic ulcer.
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