BMS-223131

Overview

BMS-223131 (Compound 1) is a potent maxi-K potassium channel opener. BMS-223131 has a strong inhibitory effect on the CYP2C9 enzyme ( IC 50 = 1.7 μM) and also shows varying degrees of inhibition on other common CYP enzymes such as CYP1A2 , CYP2C19 , CYP2D6 , and CYP3A4 . BMS-223131 can enhance the outward current mediated by maxi-K, by promoting K + efflux to hyperpolarize the cell membrane and reducing Ca 2+ influx. BMS-223131 can be used for the research of neurological disease , such as stroke.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-19397
• CAS No.: 275375-69-4
• Molecular Formula: C18H13ClF3NO3
• Molecular Weight: 383.75
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source