UBP-282 is a potent, selective and competitive AMPA and kainate receptor antagonist. UBP-282 inhibits the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) with an IC 50 value of 10.3 μM. UBP-282 antagonizes kainate -induced depolarisations of dorsal roots with a pA 2 value of 4.96.
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