Zanapezil free base

Overview

Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase ( AChE ) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex ( IC 50 =51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K i values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Cholinesterase (ChE)

Product Information

• Catalog No.: HY-19651
• CAS No.: 142852-50-4
• Molecular Formula: C25H32N2O
• Molecular Weight: 376.53
• Purity: 99.23%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.67 mg/mL (4.44 mM); Clear solution
• Availability: In-stock

Source

Original product source