BIBS 39

Overview

BIBS 39 is a non-peptide angiotensin II receptor antagonist with antihypertensive activity, with higher affinity for the AT1 receptor than for the AT2 receptor . BIBS 39 competitively blocks AT1-mediated vasoconstriction and pressor responses, and effectively inhibits the activity of the renin-angiotensin-aldosterone system. BIBS 39 reduces diastolic blood pressure and induces mild, transient reflex tachycardia, with no off-target functional activity on the norepinephrine, K + /Cl − or vasopressin pathways. BIBS 39 can be used in research related to hypertension and renal hypertension [1] [ 2 ] [3] .

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Hypertension | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Angiotensin Receptor

Product Information

• Catalog No.: HY-19732
• CAS No.: 133085-33-3
• Molecular Formula: C32H36N4O3
• Molecular Weight: 524.65
• Purity: 99.70%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 1.25 mg/mL (2.38 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source