VU0357017 (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M 1 muscarinic acetylcholine receptor , with an EC 50 of 477 nM. VU0357017 is highly selective for M 1 and has no activity at M 2 -M 5 up to the highest concentrations tested (30 μM). VU0357017 can be used for the research of Alzheimer’s disease and schizophrenia.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mAChR
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