Avitinib

Overview

Avitinib (Abivertinib) is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR . Avitinib is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib shows anticancer effects.

Application

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Product Information

• Catalog No.: HY-19816
• CAS No.: 1557267-42-1
• Molecular Formula: C26H26FN7O2
• Molecular Weight: 487.53
• Purity: 99.95%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 3.57 mg/mL (7.32 mM); Clear solution
• Availability: In-stock

Source

Original product source