NSC45586 sodium

Overview

NSC45586 sodium is an inhibitor of PHLPP . NSC45586 sodium targets the PP2C phosphatase domains of PHLPP1 and PHLPP2 , blocks the phosphatase activity of PHLPP , increases the expression level of FOXO1 in the nucleus, and reduces the protein expression of PHLPP1 . NSC45586 sodium activates the AKT survival signaling pathway, enhances IGF-1 -induced AKT activation, and inhibits the phosphorylation of AKT / ERK under basal conditions. NSC45586 sodium reduces staurosporine-induced neuronal death, preserves notochord cell morphology and KRT19 expression, inhibits cell apoptosis ( apoptosis ), improves the viability and proliferation of nucleus pulposus cells, upregulates the expression of ACAN / SOX9 , and downregulates the expression of MMP13 . NSC45586 sodium binds tightly to bovine serum albumin ( bovine serum albumin ), and exerts a more significant effect on nucleus pulposus in male individuals. NSC45586 sodium can be used in studies related to global cerebral ischemia and intervertebral disc degeneration.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Spinal Disease | Products > Disease Areas > Cerebrovascular Disease | Products > Disease Areas > Disc Degeneration | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Ser/Thr Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MMP

Product Information

• Catalog No.: HY-19820A
• CAS No.: 6300-44-3
• Molecular Formula: C20H17N6NaO3
• Molecular Weight: 412.38
• Purity: 98.0%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source