Ruboxistaurin-d 6 (hydrochloride) is the deuterium labeled Ruboxistaurin hydrochloride. Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC 50 of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC 50 of 5.9 nM.
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