AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with IC 50 s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1, respectively. AZ-PFKFB3-67 reduces MCL-1 . AZ-PFKFB3-67 has neuroprotective activity.
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