LXRβ ligand 1

Overview

LXRβ ligand 1 is a LXR β ligand-binding domain agonist, with an EC 50 of 57 μM and a K i of 28 μM against human LXR β. LXRβ ligand 1 forms hydrogen bonds with His435, stabilizes the His-Trp activation switch, and locks the ligand-binding domain in an agonist conformation; its tert-butyl moiety occupies a hydrophobic subpocket, while its phenyl moiety forms a π-π stacking interaction with Phe329. LXRβ ligand 1 serves as a structural unit for the development of LXRβ modulators.

Application

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Product Information

• Catalog No.: HY-33821
• CAS No.: 171049-41-5
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.32
• Purity: 99.40%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source