BIIE-0246 (Standard) is the analytical standard of BIIE-0246 ( HY-101986 ). This product is intended for research and analytical applications. BIIE-0246 (AR-H 053591) is a potent and selective NPY2R ( neuropeptide Y receptor 2) antagonist with an IC 50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy.
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