Tosylate-DPA-714

Overview

Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 ( HY-122607 ). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein ( TSPO ) with a K i of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors ( benzodiazepine receptor ). As a radiolabeling precursor, Tosylate-DPA-714 reacts with 18 F via nucleophilic aliphatic substitution to form 18 F-DPA-714, enabling specific targeted binding to TSPO. 18 F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > Drug Intermediate | Products > Signaling Pathways > TSPO

Product Information

• Catalog No.: HY-400882
• CAS No.: 958233-17-5
• Molecular Formula: C29H34N4O5S
• Molecular Weight: 550.67
• Purity: 98.78%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (9.08 mM); Clear solution
• Availability: In-stock

Source

Original product source