BEPP hydrochloride is a double-stranded RNA-dependent protein kinase ( PKR ) modulator. BEPP hydrochloride enhances the phosphorylation levels of PKR and eIF2α, activates caspase-3 , upregulates the pro-apoptotic protein BAX , and downregulates the anti-apoptotic protein Bcl-2 . BEPP hydrochloride inhibits vaccinia virus replication and exhibits selective cytotoxicity in cells expressing PKR . BEPP hydrochloride can be used in research related to cancer and viral infections.
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