(S,R,S)-AHPC-Me hydrochloride

Overview

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC 50 <1 nM.

Application

Products | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Signaling Pathways > Ligands for E3 Ligase

Product Information

• Catalog No.: HY-42424
• CAS No.: 1948273-03-7
• Molecular Formula: C23H33ClN4O3S
• Molecular Weight: 481.05
• Purity: 99.95%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution
• Availability: In-stock

Source

Original product source