Sorafenib tosylate

Overview

Sorafenib (Bay 43-9006) tosylate is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases ( VEGFR-2 , VEGFR-3 ) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib tosylate induces cell cycle arrest, autophagy , apoptosis , and PARP cleavage, reduces Bcl-2 , Bcl-XL , cyclin D1 levels, and activates Bak and Bax . Sorafenib tosylate inhibits tumor growth and metastasis in mouse and rat models. Sorafenib tosylate can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.

Application

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Product Information

• Catalog No.: HY-10201A
• CAS No.: 475207-59-1
• Molecular Formula: C28H24ClF3N4O6S
• Molecular Weight: 637.03
• Purity: 99.98%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (3.92 mM); Clear solution
• Availability: In-stock

Source

Original product source