EN450

Overview

EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB . EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D . EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.

Application

Products | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > E1/E2/E3 Enzyme

Product Information

• Catalog No.: HY-49444
• CAS No.: 793719-01-4
• Molecular Formula: C11H13ClN2O3S
• Molecular Weight: 288.76
• Purity: 98.59%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (8.66 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source