Crizotinib

Overview

Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.

Application

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Product Information

• Catalog No.: HY-50878
• CAS No.: 877399-52-5
• Molecular Formula: C21H22Cl2FN5O
• Molecular Weight: 450.34
• Purity: 99.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 1.25 mg/mL (2.78 mM); Clear solution
• Availability: In-stock

Source

Original product source