Erlotinib (Standard)

Overview

Erlotinib Standard (CP-358774 Standard) is the analytical standard of Erlotinib ( HY-50896 ). This product is intended for research and analytical applications. Erlotinib (CP-358774) is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib also acts as a substrate and inhibitor of OATP2B1 , with an IC 50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2 , GSK-3β and β-catenin signaling pathways, as well as the deposition of fibronectin, α-SMA, collagen and renal injury markers. Erlotinib is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib can be used in research related to non-small cell lung cancer , gastric cancer , papillary renal cell carcinoma, EGFR inhibitor resistance and renal fibrosis.

Application

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Product Information

• Catalog No.: HY-50896R
• CAS No.: 183321-74-6
• Molecular Formula: C22H23N3O4
• Molecular Weight: 393.44
• Purity: 99.97%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source