ABT-737-d 8

Overview

ABT 737-d 8 is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2 , Bcl-x L and Bcl-w inhibitor with EC 50 s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Others | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Biochemical Assay Reagents

Product Information

• Catalog No.: HY-50907S
• CAS No.: 1217686-68-4
• Molecular Formula: C42H37D8ClN6O5S2
• Molecular Weight: 821.48
• Purity: 99.11%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source